| http://purl.uniprot.org/citations/29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29874574 | http://www.w3.org/2000/01/rdf-schema#comment | "Metabolic pathways, once seen as a mere consequence of cell states, have emerged as active players in dictating different cellular events such as proliferation, self-renewal, and differentiation. Several studies have reported a role for folate-dependent one-carbon (1C) metabolism in stem cells; however, its exact mode of action and how it interacts with other cues are largely unknown. Here, we report a link between the Eph:ephrin cell-cell communication pathway and 1C metabolism in controlling neural stem cell differentiation. Transcriptional and functional analyses following ephrin stimulation revealed alterations in folate metabolism-related genes and enzymatic activity. In vitro and in vivo data indicate that Eph-B forward signaling alters the methylation state of H3K4 by regulating 1C metabolism and locks neural stem cell in a differentiation-ready state. Our study highlights a functional link between cell-cell communication, metabolism, and epigenomic remodeling in the control of stem cell self-renewal."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.05.005"xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/author | "Davy A."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/author | "Iacovoni J.S."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/author | "Jungas T."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/author | "Audouard C."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/author | "Fawal M.A."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/author | "Kischel A."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/pages | "2864-2873.e7"xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/title | "Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation."xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/29874574 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29874574 |
| http://purl.uniprot.org/citations/29874574 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29874574 |
| http://purl.uniprot.org/uniprot/#_D3Z783-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_D3YYP9-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_D3YXX3-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_P52795-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_P52800-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_A2AR81-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_A4FUQ9-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_F6RSU6-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |
| http://purl.uniprot.org/uniprot/#_F6Q4H2-mappedCitation-29874574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29874574 |