| http://purl.uniprot.org/citations/29884877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29884877 | http://www.w3.org/2000/01/rdf-schema#comment | "The wap gene encodes a single whey acidic protein (WAP) domain-containing peptide from Chinese white shrimp (Fenneropenaeus chinensis), which shows broad-spectrum antimicrobial activities and proteinase inhibitory activities in vitro. To explore the medical applications of the WAP peptide, a wap gene transgenic Drosophila melanogaster was constructed. In wap-expressing flies, high expression levels of wap gene (>100 times) were achieved, in contrast to those of control flies, by qRT-PCR analysis. The wap gene expression was associated with increased resistance to microbial infection and decreased bacterial numbers in the flies. In addition, the WAP protein extract from wap-expressing flies, compared with control protein extract from control flies, showed improved antimicrobial activities against broad Gram-positive and Gram-negative bacteria, including the clinical drug resistant bacterium of methicillin-resistant S. aureus (MRSA), improved protease inhibitor activities against crude proteinases and commercial proteinases, including elastase, subtilis proteinase A, and proteinase K in vitro, and improved growth rate and microbial resistance, as well as wound-healing in loach and mouse models. These results suggest that wap-expressing flies could be used as a food additive in aquaculture to prevent infections and a potential antibacterial for fighting drug-resistant bacteria."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-26466-6"xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Qi M."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Arefin B."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/author | "Luan Y."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/pages | "8779"xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/title | "Expression of the Shrimp wap gene in Drosophila elicits defense responses and protease inhibitory activity."xsd:string |
| http://purl.uniprot.org/citations/29884877 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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