| http://purl.uniprot.org/citations/29898394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29898394 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoietic stem cells (HSCs) comprise a heterogeneous population exhibiting self-renewal and differentiation capabilities; however, the mechanisms involved in maintaining this heterogeneity remain unclear. Here, we show that SATB1 is involved in regulating HSC heterogeneity. Results in conditional Satb1-knockout mice revealed that SATB1 was important for the self-renewal and lymphopoiesis of adult HSCs. Additionally, HSCs from Satb1/Tomato-knockin reporter mice were classified based on SATB1/Tomato intensity, with transplantation experiments revealing stronger differentiation toward the lymphocytic lineage along with high SATB1 levels, whereas SATB1- HSCs followed the myeloid lineage in agreement with genome-wide transcription and cell culture studies. Importantly, SATB1- and SATB1+ HSC populations were interconvertible upon transplantation, with SATB1+ HSCs showing higher reconstituting and lymphopoietic potentials in primary recipients relative to SATB1- HSCs, whereas both HSCs exhibited equally efficient reconstituted lympho-hematopoiesis in secondary recipients. These results suggest that SATB1 levels regulate the maintenance of HSC multipotency, with variations contributing to HSC heterogeneity."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.05.042"xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Ishibashi T."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Satoh Y."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Takeda J."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Tokunaga M."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Oritani K."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Kanakura Y."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Doi Y."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Sudo T."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Okuzaki D."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Shibayama H."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Tanimura A."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Kohwi-Shigematsu T."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Ichii M."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Ezoe S."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/author | "Shingai Y."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/pages | "3223-3235"xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/title | "Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate."xsd:string |
| http://purl.uniprot.org/citations/29898394 | http://purl.uniprot.org/core/volume | "23"xsd:string |