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http://purl.uniprot.org/citations/29903884 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell fate decisions require appropriate regulation of key genes. Sox9, a direct target of SRY, is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility techniques, transgenic assays, and genome editing revealed several novel gonadal regulatory elements in the 2-megabase gene desert upstream of Sox9 Although others are redundant, enhancer 13 (Enh13), a 557-base pair element located 565 kilobases 5' from the transcriptional start site, is essential to initiate mouse testis development; its deletion results in XY females with Sox9 transcript levels equivalent to those in XX gonads. Our data are consistent with the time-sensitive activity of SRY and indicate a strict order of enhancer usage. Enh13 is conserved and embedded within a 32.5-kilobase region whose deletion in humans is associated with XY sex reversal, suggesting that it is also critical in humans."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aas9408"xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Maatouk D.M."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Futtner C.R."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Wood S."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Lovell-Badge R."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Poulat F."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Sekido R."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Samson S.C."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Salamone I.M."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Gonen N."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/author | "Garcia-Moreno S.A."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/pages | "1469-1473"xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/title | "Sex reversal following deletion of a single distal enhancer of Sox9."xsd:string |
http://purl.uniprot.org/citations/29903884 | http://purl.uniprot.org/core/volume | "360"xsd:string |
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