| http://purl.uniprot.org/citations/29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29908303 | http://www.w3.org/2000/01/rdf-schema#comment | "Furfuryl alcohol (FFA) is a heat-induced food contaminant. Conversion by sulfotransferases (SULT) yields 2-sulfoxymethylfuran, which is prone to react with DNA and proteins. In order to monitor the internal FFA exposure we developed a technique for the mass spectrometric quantification of the adduct N-((furan-2-yl)methyl)-valine (FFA-Val) after cleavage from the N-termini of hemoglobin. In the current study the method was applied to investigate the influence of different SULT forms on the adduct formation in wild-type mice and three genetically modified mouse models treated with FFA. Two lines were devoid of endogenous Sult1a1 or Sult1d1, while another mouse line carried a transgene of human SULT1A1/1A2 in the Sult1a1/1d1 double knockout background. The Sult1d1 knockout did not influence adduct formation, whereas the lack of Sult1a1 reduced mean FFA-Val levels by 80% and 58% in male and female mice, respectively, in comparison to FFA-treated wild-type mice. The levels of FFA-Val in the humanized mice were elevated by factors of 2.7 (males) and 2.2 (females) as compared to the wild-type, indicating that SULT1A1/1A2 play a central role for FFA bioactivation also in humans. The excellent correlation between adduct levels in hepatic DNA and hemoglobin (r2 = 0.97) indicated that 2-sulfoxymethylfuran of hepatic origin is sufficiently stable to enter circulation and pass the cellular membrane of erythrocytes. This is a prerequisite for the application of FFA-Val as a biomarker of internal FFA exposure."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxlet.2018.06.008"xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/author | "Glatt H."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/author | "Lampen A."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/author | "Meinl W."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/author | "Abraham K."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/author | "Monien B.H."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/author | "Sachse B."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/name | "Toxicol Lett"xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/pages | "173-178"xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/title | "Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2."xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://purl.uniprot.org/core/volume | "295"xsd:string |
| http://purl.uniprot.org/citations/29908303 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29908303 |
| http://purl.uniprot.org/citations/29908303 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29908303 |
| http://purl.uniprot.org/uniprot/#_P52840-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_E9QNL5-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_P50225-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_P50226-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_Q3UZZ6-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_Q8BT67-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_Q3TV15-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_Q91W19-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |
| http://purl.uniprot.org/uniprot/#_Q59GG0-mappedCitation-29908303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29908303 |