http://purl.uniprot.org/citations/29909746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/29909746 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundDecidual γδ T cells are known to regulate the function of trophoblasts at the maternal-fetal interface; however, little is known about the molecular mechanisms of cross talk between trophoblast cells and decidual γδ T cells.MethodsExpression of chemokine C-X-C motif ligand 6 (CXCL16) and its receptor CXCR6 was evaluated in first-trimester human villus and decidual tissues by immunohistochemistry. γδ T cells were isolated from first-trimester human deciduae and cocultured with JEG3 trophoblast cells. Cell proliferation and apoptosis-related molecules, together with cytotoxicity factor and cytokine production, were measured by flow cytometry analysis.ResultsExpression of CXCL16 and CXCR6 was reduced at the maternal-fetal interface in patients who experienced unexplained recurrent spontaneous abortion as compared to healthy pregnancy women. With the administration of pregnancy-related hormones or coculture with JEG3 cells, CXCR6 expression was upregulated on decidual γδ T cells. CXCL16 derived from JEG3 cells caused a decrease in granzyme B production of decidual γδ T cells. In addition, decidual γδ T cells educated by JEG3-derived CXCL16 upregulated the expression of Bcl-xL in JEG3 cells.ConclusionThis study suggested that the CXCL16/CXCR6 axis may contribute to maintaining normal pregnancy by reducing the secretion of cytotoxic factor granzyme B of decidual γδ T cells and promoting the expression of antiapoptotic marker Bcl-xL of trophoblasts."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.org/dc/terms/identifier | "doi:10.1177/1933719118777638"xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/author | "Xu X.H."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/author | "Xu C.J."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/author | "Zhou W.J."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/author | "Li M.Q."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/author | "Jin L.P."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/author | "Fan D.X."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/name | "Reprod Sci"xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/pages | "532-542"xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/title | "Trophoblast-Derived CXCL16 Decreased Granzyme B Production of Decidual gammadelta T Cells and Promoted Bcl-xL Expression of Trophoblasts."xsd:string |
http://purl.uniprot.org/citations/29909746 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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