| http://purl.uniprot.org/citations/29909984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29909984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29909984 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular proTGF-β is covalently linked to "milieu" molecules in the matrix or on cell surfaces and is latent until TGF-β is released by integrins. Here, we show that LRRC33 on the surface of microglia functions as a milieu molecule and enables highly localized, integrin-αVβ8-dependent TGF-β activation. Lrrc33-/- mice lack CNS vascular abnormalities associated with deficiency in TGF-β-activating integrins but have microglia with a reactive phenotype and after 2 months develop ascending paraparesis with loss of myelinated axons and death by 5 months. Whole bone marrow transplantation results in selective repopulation of Lrrc33-/- brains with WT microglia and halts disease progression. The phenotypes of WT and Lrrc33-/- microglia in the same brain suggest that there is little spreading of TGF-β activated from one microglial cell to neighboring microglia. Our results suggest that interactions between integrin-bearing cells and cells bearing milieu molecule-associated TGF-β provide localized and selective activation of TGF-β."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2018.05.027"xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2018.05.027"xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Springer T.A."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Springer T.A."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Bronson R.T."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Bronson R.T."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Garrison B.S."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Garrison B.S."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Jiang A."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Jiang A."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Franco C."xsd:string |
| http://purl.uniprot.org/citations/29909984 | http://purl.uniprot.org/core/author | "Franco C."xsd:string |