| http://purl.uniprot.org/citations/29920275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29920275 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of metastatic organotropism in pancreatic ductal a denocarcinoma (PDAC) remains poorly understood. We demonstrate, using multiple mouse models, that liver and lung metastatic organotropism is dependent upon p120catenin (p120ctn)-mediated epithelial identity. Mono-allelic p120ctn loss accelerates KrasG12D-driven pancreatic cancer formation and liver metastasis. Importantly, one p120ctn allele is sufficient for E-CADHERIN-mediated cell adhesion. By contrast, cells with bi-allelic p120ctn loss demonstrate marked lung organotropism; however, rescue with p120ctn isoform 1A restores liver metastasis. In a p120ctn-independent PDAC model, mosaic loss of E-CADHERIN expression reveals selective pressure for E-CADHERIN-positive liver metastasis and E-CADHERIN-negative lung metastasis. Furthermore, human PDAC and liver metastases support the premise that liver metastases exhibit predominantly epithelial characteristics. RNA-seq demonstrates differential induction of pathways associated with metastasis and epithelial-to-mesenchymal transition in p120ctn-deficient versus p120ctn-wild-type cells. Taken together, P120CTN and E-CADHERIN mediated epithelial plasticity is an addition to the conceptual framework underlying metastatic organotropism in pancreatic cancer."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2018.05.025"xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Suzuki K."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Schneider G."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Wirth M."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Reynolds A.B."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Simon L."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Feldmann K."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Rustgi A.K."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Weichert W."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Klein-Szanto A.J."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Reichert M."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Saur D."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Moreira L."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Pitarresi J.R."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Schlitter A.M."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Adsay N.V."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Bakir B."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Maddipati R."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Rhim A.D."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Schuck K."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Kriegsmann M."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Pehlivanoglu B."xsd:string |
| http://purl.uniprot.org/citations/29920275 | http://purl.uniprot.org/core/author | "Memis B."xsd:string |