| http://purl.uniprot.org/citations/29921878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29921878 | http://www.w3.org/2000/01/rdf-schema#comment | "Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and NS1-BP regulate IAV M segment splicing, but the mechanistic details were unknown. Here we show NS1-BP and hnRNP K bind M mRNA downstream of the M2 5' splice site (5'ss). NS1-BP binds most proximal to the 5'ss, partially overlapping the U1 snRNP binding site, while hnRNP K binds further downstream and promotes U1 snRNP recruitment. Mutation of either or both the hnRNP K and NS1-BP-binding sites results in M segment mis-splicing and attenuated IAV replication. Additionally, we show that hnRNP K and NS1-BP regulate host splicing events and that viral infection causes mis-splicing of some of these transcripts. Therefore, our proposed mechanism of hnRNP K/NS1-BP mediated IAV M splicing provides potential targets of antiviral intervention and reveals novel host functions for these proteins."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-04779-4"xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Munoz-Moreno R."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Thompson M.G."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Lindberg J."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Mallory M.J."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Fontoura B.M.A."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Bhat P."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Lynch K.W."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Gazzara M.R."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/author | "Roytenberg R."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/pages | "2407"xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/title | "Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29921878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29921878 |
| http://purl.uniprot.org/citations/29921878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29921878 |
| http://purl.uniprot.org/uniprot/#_B3KSM1-mappedCitation-29921878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29921878 |
| http://purl.uniprot.org/uniprot/#_B4DFF1-mappedCitation-29921878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29921878 |
| http://purl.uniprot.org/uniprot/#_B3KMY8-mappedCitation-29921878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29921878 |
| http://purl.uniprot.org/uniprot/#_B3KU16-mappedCitation-29921878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29921878 |