| http://purl.uniprot.org/citations/29925002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29925002 | http://www.w3.org/2000/01/rdf-schema#comment | "Exposure to cold temperature is well known to upregulate heat shock protein (Hsp) expression and recruit and/or activate brown adipose tissue and beige adipocytes in humans and animals. However, whether and how Hsps regulate adipocyte function for energy homeostatic responses is poorly understood. Here, we demonstrate a critical role of Hsp20 as a negative regulator of adipocyte function. Deletion of Hsp20 enhances non-shivering thermogenesis and suppresses inflammatory responses, leading to improvement of glucose and lipid metabolism under both chow diet and high-fat diet conditions. Mechanistically, Hsp20 controls adipocyte function by interacting with the subunit of the ubiquitin ligase complex, F-box only protein 4 (FBXO4), and regulating the ubiquitin-dependent degradation of peroxisome proliferation activated receptor gamma (PPARγ). Indeed, Hsp20 deficiency mimics and enhances the pharmacological effects of the PPARγ agonist rosiglitazone. Together, our findings suggest a role of Hsp20 in mediating adipocyte function by linking β-adrenergic signaling to PPARγ activity."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.05.065"xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Deng S."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Huang K."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Gu H."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Mu X."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Peng T."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Holland J."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Perez-Tilve D."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Fan G.C."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Jegga A.G."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "McNamara R.K."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Yates E."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/author | "Essandoh K."xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29925002 | http://purl.uniprot.org/core/pages | "3607-3620"xsd:string |