| http://purl.uniprot.org/citations/29925830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29925830 | http://www.w3.org/2000/01/rdf-schema#comment | "Controlled macrophage differentiation and activation in the initiation and resolution of inflammation is crucial for averting progression to chronic inflammatory and autoimmune diseases. Here we show a negative feedback mechanism for proinflammatory IFN-γ activation of macrophages driven by macrophage-associated matrix metalloproteinase 12 (MMP12). Through C-terminal truncation of IFN-γ at 135Glu↓Leu136 the IFN-γ receptor-binding site was efficiently removed thereby reducing JAK-STAT1 signaling and IFN-γ activation of proinflammatory macrophages. In acute peritonitis this signature was absent in Mmp12 -/- mice and recapitulated in Mmp12 +/+ mice treated with a MMP12-specific inhibitor. Similarly, loss-of-MMP12 increases IFN-γ-dependent proinflammatory markers and iNOS+/MHC class II+ macrophage accumulation with worse lymphadenopathy, arthritic synovitis and lupus glomerulonephritis. In active human systemic lupus erythematosus, MMP12 levels were lower and IFN-γ higher compared to treated patients or healthy individuals. Hence, macrophage proteolytic truncation of IFN-γ attenuates classical activation of macrophages as a prelude for resolving inflammation."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-04717-4"xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Eckhard U."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Overall C.M."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Solis N."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Dive V."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Pavlidis P."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Klein T."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Dufour A."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Mark J."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Kappelhoff R."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Rozmus J."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Bellac C.L."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Jobin P."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Fortelny N."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/author | "Barbour S.J."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/pages | "2416"xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/title | "C-terminal truncation of IFN-gamma inhibits proinflammatory macrophage responses and is deficient in autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29925830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29925830 |
| http://purl.uniprot.org/citations/29925830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29925830 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-29925830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29925830 |