| http://purl.uniprot.org/citations/29925947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29925947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29925947 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA double-strand breaks repaired by non-homologous end joining display limited DNA end-processing and chromosomal mobility. By contrast, double-strand breaks undergoing homology-directed repair exhibit extensive processing and enhanced motion. The molecular basis of this movement is unknown. Here, using Xenopus laevis cell-free extracts and mammalian cells, we establish that nuclear actin, WASP, and the actin-nucleating ARP2/3 complex are recruited to damaged chromatin undergoing homology-directed repair. We demonstrate that nuclear actin polymerization is required for the migration of a subset of double-strand breaks into discrete sub-nuclear clusters. Actin-driven movements specifically affect double-strand breaks repaired by homology-directed repair in G2 cell cycle phase; inhibition of actin nucleation impairs DNA end-processing and homology-directed repair. By contrast, ARP2/3 is not enriched at double-strand breaks repaired by non-homologous end joining and does not regulate non-homologous end joining. Our findings establish that nuclear actin-based mobility shapes chromatin organization by generating repair domains that are essential for homology-directed repair in eukaryotic cells."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-018-0237-5"xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-018-0237-5"xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Chang W."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Chang W."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Gottesman M.E."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Gottesman M.E."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Aparicio T."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Aparicio T."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Gautier J."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Gautier J."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Gundersen G.G."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Gundersen G.G."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Schrank B.R."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/author | "Schrank B.R."xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/29925947 | http://purl.uniprot.org/core/name | "Nature"xsd:string |