| http://purl.uniprot.org/citations/29928002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29928002 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently several studies demonstrated a role for the Wnt pathway in lymphocyte development and self-renewal of hematopoietic stem cells (HSCs). B-1 cells constitute a separate lineage of B lymphocytes, originating during fetal hematopoiesis, expressing lymphoid and myeloid markers and possessing self-renewal ability, similar to early hematopoietic progenitors and HSCs. A plethora of studies have shown an important role for the evolutionary conserved Wnt pathway in the biology of HSCs and T lymphocyte development. Our previous data demonstrated abundant expression of Wnt pathway components by B-1 cells, including Wnt ligands and receptors. Here we report that the canonical Wnt pathway is activated in B-1 cell precursors, but not in mature B-1 cells. However, both B-1 precursors and B-1 cells are able to respond to Wnt ligands in vitro. Canonical Wnt activity promotes proliferation of B-1 cells, while non-canonical Wnt signals induce the expansion of B-1 precursors. Interestingly, using a co-culture system with OP9 cells, Wnt3a stimulus supported the generation of B-1a cells. Taking together, these results indicate that B-1 cells and their progenitors are differentially responsive to Wnt ligands, and that the balance of activation of canonical and non-canonical Wnt signaling may regulate the maintenance and differentiation of different B-1 cell subsets."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0199332"xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/author | "Staal F.J.T."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/author | "de Oliveira V.C."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/author | "Popi A.F."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/author | "Osugui L."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/author | "Sodre A.C.P."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/author | "de Roo J.J."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/pages | "e0199332"xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/title | "B-1 cells and B-1 cell precursors prompt different responses to Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/29928002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29928002 |
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