| http://purl.uniprot.org/citations/29940774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29940774 | http://www.w3.org/2000/01/rdf-schema#comment | "A total of 56 RCC patients with staging ≥ pT1b were enrolled in a prospective study to assess the prognostic importance of serum levels of osteopontin (OP), stanniocalcin-1 (SC), FGF-23, alpha Klotho and 25-OH-D at the time of diagnosis in renal cell carcinoma (RCC) patients. The relationship between the serum level of the analyzed parameters and recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) was examined, and our control group consisted of 20 patients without cancer. The levels of osteopontin, stanniocalcin-1, FGF-23 and alpha Klotho were determined by Enzyme-Linked Immunosorbent Assay (ELISA) and 25-OH-D by chemiluminiscence immunoanalysis (CLIA). The follow-up period median was 46 months. Renal cell carcinoma recurred in 9 patients and 20 patients died during follow-up; 12 of them from RCC. The level of osteopontin and stanniocalcin-1 varied between the control group and RCC patients (at p=0.02 and p=0.0003). Higher levels of stanniocalcin-1 were detected in the metastatic RCC group than in the localized RCC group (p=0.003). Only the stanniocalcin-1 level at the time of surgery was associated with RFS (p=0.0004). Both OS and CCS were associated with the osteopontin, stanniocalcin-1 and FGF preoperative level. Patients with stanniocalcin-1 level over 1,277 pg/ml and osteopontin level over 100 ng/ml had 17.8 times higher and 7.9 times higher risk of dying from RCC progression, respectively (p<0.001 and p=0.002). High levels of osteopontin, stanniocalcin-1 and FGF 23 at the time of surgery are important prognostic factors related to CSS and OS. Patients with high stanniocalcin-1 level were at risk of tumor recurrence."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.org/dc/terms/identifier | "doi:10.4149/neo_2018_171123n759"xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/author | "Sobotka R."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/author | "Soukup V."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/author | "Kalousova M."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/author | "Zima T."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/author | "Capoun O."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/author | "Hanus T."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/name | "Neoplasma"xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/pages | "958-964"xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/title | "The importance of serum osteopontin and stanniocalcin-1 in renal cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/29940774 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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