| http://purl.uniprot.org/citations/29945867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29945867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29945867 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuroendocrine cells in the pineal gland release melatonin during the night and, in teleosts, are directly photoreceptive. During development of the pineal complex, a small number of cells migrate leftward away from the pineal anlage to form the parapineal cell cluster, a process that is crucial for asymmetrical development of the bilateral habenular nuclei. Here, we show that, throughout zebrafish embryonic development, the brain-specific homeobox (bsx) gene is expressed in all cell types of the pineal complex. We identified Bmp and Noto/Flh as major regulators of bsx expression in the pineal complex. Upon loss of Bsx through the generation of a targeted mutation, embryos fail to form a parapineal organ and develop right-isomerized habenulae. Crucial enzymes in the melatonin biosynthesis pathway are not expressed, suggesting the absence of melatonin from the pineal gland in bsx mutants. Several genes involved in rod-like or cone-like phototransduction are also abnormally expressed, indicating that Bsx has a pivotal role in the differentiation of multiple cell types in the zebrafish pineal complex."xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.163477"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.163477"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/author | "Driever W."xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/author | "Driever W."xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/author | "Schredelseker T."xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/author | "Schredelseker T."xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/pages | "dev163477"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/pages | "dev163477"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/title | "Bsx controls pineal complex development. ."xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/title | "Bsx controls pineal complex development."xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/volume | "145"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://purl.uniprot.org/core/volume | "145"xsd:string |
| http://purl.uniprot.org/citations/29945867 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29945867 |
| http://purl.uniprot.org/citations/29945867 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29945867 |
| http://purl.uniprot.org/citations/29945867 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29945867 |
| http://purl.uniprot.org/citations/29945867 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29945867 |
| http://purl.uniprot.org/uniprot/Q9PTX9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/29945867 |
| http://purl.uniprot.org/uniprot/Q7SZV1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/29945867 |