| http://purl.uniprot.org/citations/29949664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29949664 | http://www.w3.org/2000/01/rdf-schema#comment | "NR4A1 (Nur77 or NGFI-B), an orphan member of the nuclear receptor superfamily, has been identified as a key regulator of the differentiation and function of myeloid, lymphoid, and mesenchymal cells. The detailed role of NR4A1 in bone biology is incompletely understood. Here, we report a role for NR4A1 as novel factor controlling the migration and recruitment of osteoclast precursors during bone remodeling. Myeloid-specific but not osteoblast-specific deletion of NR4A1 resulted in osteopenia due to an increase in the number of bone-lining osteoclasts. Although NR4A1-deficient osteoclast precursors displayed a regular differentiation into mature osteoclasts, they showed a hyper-motile phenotype that was largely dependent on increased osteopontin expression, suggesting that expression of NR4A1 negatively controlled osteopontin-mediated recruitment of osteoclast precursors to the trabecular bone. Pharmacological activation of NR4A1, in turn, inhibited osteopontin expression and osteopontin-dependent migration of osteoclast precursors resulted in reduced abundance of bone-resorbing osteoclasts in vivo as well as in an ameliorated bone loss after ovariectomy in mice. This study identifies NR4A1 as a crucial player in the regulation of osteoclast biology and bone remodeling and highlights this nuclear receptor as a promising target for therapeutic intervention during the treatment of osteoporosis. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbmr.3533"xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Herrmann M."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Distler J."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Fabry B."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Rothe T."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Bohm C."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Tuckermann J."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Goldmann W.H."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Schett G."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Ipseiz N."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Scholtysek C."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Stoll C."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Kronke G."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Weidner D."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Stenzel M."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Palumbo-Zerr K."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Czerwinski T."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Klej A."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/author | "Krishnacoumar B."xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/pages | "2035-2047"xsd:string |
| http://purl.uniprot.org/citations/29949664 | http://purl.uniprot.org/core/title | "NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover."xsd:string |