| http://purl.uniprot.org/citations/29949917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29949917 | http://www.w3.org/2000/01/rdf-schema#comment | "Virus infections induce sensitive antiviral responses within the host cell. The RNA helicase retinoic acid-inducible gene I (RIG-I) is a key sensor of influenza virus RNA that induces the expression of antiviral type I interferons. Recent evidence suggests a complex pattern of RIG-I regulation involving multiple interactions and cellular sites. In an approach employing affinity purification and quantitative mass spectrometry, we identified proteins with increased binding to RIG-I in response to influenza B virus infection. Among them was the RIG-I related RNA helicase DEAD box helicase 6 (DDX6), a known component of cytoplasmic mRNA-ribonucleoprotein (mRNP) granules like P-bodies and stress granules (SGs). RIG-I and DDX6 both localized to the cytosol and were detected in virus-induced SGs. Coimmunoprecipitation assays detected a basal level of complexes harboring RIG-I and DDX6 that increased after infection. Functionally, DDX6 augmented RIG-I mediated induction of interferon (IFN)-β expression. Notably, DDX6 was found to bind viral RNA capable to stimulate RIG-I. These findings imply a novel function for DDX6 as an RNA co-sensor and signaling enhancer for RIG-I."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms19071877"xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/author | "Wolff T."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/author | "Budt M."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/author | "Arnold U."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/author | "Saenger S."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/author | "Paki K."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/author | "Sadewasser A."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/author | "Nunez R.D."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/pages | "E1877"xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/title | "The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling."xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/29949917 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29949917 |
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