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http://purl.uniprot.org/citations/29957081http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29957081http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Previous studies reported that depletion of Bcl-2 has a protective effect against allergic diseases. Furthermore, recently our study showed that anticancer drug has antiallergic inflammatory effect. An anticancer agent ABT-737 is an inhibitor of Bcl-2 and has an anti-inflammatory effect. However, the antiallergic inflammatory activity of ABT-737 is still unknown. Here, we aimed to explore the anti-atopic dermatitis (AD) activity and the mechanism of ABT-737 in AD models.

Materials and methods

HaCaT cells were used for in vitro experiments. To evaluate the effect of ABT-737 in vivo model, BalB/c mice were orally administered ABT-737 for 6 weeks in 2,4-dinitrofluorobenzene (DNFB)-induced AD-like murine model. Major assays were enzyme-linked immunosorbent assay, reverse transcription-PCR, caspase-1 assay, histamine assay, and H&E staining.

Results

ABT-737 significantly decreased thymic stromal lymphopoietin (TSLP) secretion and caspase-1 activity in activated HaCaT cells. In DNFB-induced AD mice, oral administration of ABT-737 alleviated clinical severity and scratching behavior. ABT-737 decreased levels of AD-related biomarkers including IgE, histamine, TSLP, and inflammatory cytokines. In addition, ABT significantly reduced caspase-1 activity in skin lesions of AD mice.

Discussion and conclusions

ABT-737 elicited an anti-AD activity via suppression of caspase-1 activation in AD in vitro and in vivo models. Therefore, this study provides important information regarding the use of anticancer drugs for controlling allergic inflammatory diseases."xsd:string
http://purl.uniprot.org/citations/29957081http://purl.org/dc/terms/identifier"doi:10.1080/08923973.2018.1482497"xsd:string
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/author"Kim H.M."xsd:string
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/author"Jeong H.J."xsd:string
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/author"Ryu K.J."xsd:string
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/name"Immunopharmacol Immunotoxicol"xsd:string
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/pages"319-326"xsd:string
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/title"Anticancer agent ABT-737 possesses anti-atopic dermatitis activity via blockade of caspase-1 in atopic dermatitis in vitro and in vivo models."xsd:string
http://purl.uniprot.org/citations/29957081http://purl.uniprot.org/core/volume"40"xsd:string
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