| http://purl.uniprot.org/citations/29958948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29958948 | http://www.w3.org/2000/01/rdf-schema#comment | "WIP (WASP interacting protein) together with N-WASP (neural Wiskott-Aldrich syndrome protein) regulates actin polymerization that is crucial for invadopodia and filopodia formation. Recently, we reported the WIP interaction with ITSN1 which is highly implicated in endo-/exocytosis, apoptosis, mitogenic signaling and cytoskeleton rearrangements. Here we demonstrate that the WIP/ITSN1 complex is involved in the transferrin receptor recycling and partially co-localizes with a marker of the fast recycling endosomes, RAB4. Moreover, ITSN1 recruits WIP to RAB4-positive vesicles upon overexpression. Our data indicate that WIP enhances the interaction of N-WASP with ITSN1 and promotes ITSN1/β-actin association. Moreover, the WIP/ITSN1-L complex facilitates formation of filopodia-like protrusions in MCF-7 cells. Thus, WIP/ITSN1 complex is involved in the cellular vesicle trafficking and actin-dependent membrane processes."xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2018.06.078"xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/author | "Rynditch A."xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/author | "Kropyvko S."xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/author | "Gryaznova T."xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/author | "Burdyniuk M."xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/author | "Gubar O."xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/pages | "49-56"xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/title | "WIP/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions."xsd:string |
| http://purl.uniprot.org/citations/29958948 | http://purl.uniprot.org/core/volume | "674"xsd:string |
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