| http://purl.uniprot.org/citations/29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29963044 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the DNA-dependent innate immune pathway plays a pivotal role in the host defense against poxvirus. Cyclic GMP-AMP synthase (cGAS) is a key cytosolic DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which triggers stimulator of interferon genes (STING), leading to type I Interferons (IFNs) production and an antiviral response. Ectromelia virus (ECTV) has emerged as a valuable model for investigating the host-Orthopoxvirus relationship. However, the role of cGas-Sting pathway in response to ECTV is not clearly understood. Here, we showed that murine cells (L929 and RAW264.7) mount type I IFN responses to ECTV that are dependent upon cGas, Sting, TANK binding kinase 1 (Tbk1), and interferon regulatory factor 3 (Irf3) signaling. Disruption of cGas or Sting expression in mouse macrophages blocked the type I IFN production and facilitated ECTV replication. Consistently, mice deficient in cGas or Sting exhibited lower type I IFN levels and higher viral loads, and are more susceptible to mousepox. Collectively, our study indicates that the cGas-Sting pathway is critical for sensing of ECTV infection, inducing the type I IFN production, and controlling ECTV replication."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.01297"xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/author | "Chen G.H."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/author | "Jin Q.W."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/author | "He X.B."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/author | "Cheng W.Y."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/author | "Jia H.J."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/author | "Jing Z.Z."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/author | "Long Z.L."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/pages | "1297"xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/title | "The cGas-Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus."xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29963044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29963044 |
| http://purl.uniprot.org/citations/29963044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29963044 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |
| http://purl.uniprot.org/uniprot/#_D3Z5R0-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |
| http://purl.uniprot.org/uniprot/#_A0A140LHE6-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |
| http://purl.uniprot.org/uniprot/#_A0A140LI96-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZC4-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD9-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |
| http://purl.uniprot.org/uniprot/#_A0A140LJE8-mappedCitation-29963044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29963044 |