| http://purl.uniprot.org/citations/29971782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29971782 | http://www.w3.org/2000/01/rdf-schema#comment | "VEGF stimulates endothelial cells as a key molecule in angiogenesis. VEGF also works as a multifunction molecule, which targets a variety of cell members in the tumor microenvironment. We aimed to reveal VEGF-related molecular mechanisms on breast cancer cells. VEGF-knocked-out MDA-MB-231 cells (231 VEGFKOex3 ) showed rounded morphology and shorter perimeter (1.6-fold, p < 0.0001). The 231 VEGFKOex3 cells also showed impaired cell migration (2.6-fold, p = 0.002). Bevacizumab treatment did not induce any change in morphology and mobility. Soluble neuropilin-1 overexpressing MDA-MB-231 cells (231 sNRP1 ) exhibited rounded morphology and shorter perimeter (1.3-fold, p < 0.0001). The 231 sNRP1 cells also showed impaired cell migration (1.7-fold, p = 0.003). These changes were similar to that of 231 VEGFKOex3 cells. As MDA-MB-231 cells express almost no VEGFR, these results indicate that the interaction between NRP1 and long isoform of VEGF containing a NRP-binding domain regulates the morphology and migration ability of MDA-MB-231 cells. Genome-wide gene expression profiling identified ARHGAP17 as one of the target genes in the downstream of the VEGF/NRP1 signal. We also show that VEGF/NRP1 signal controls filopodia formation of the cells by modulating Cdc42 activity via ARHGAP17. Among 1,980 breast cancer cases from a public database, the ratio of VEGF and SEMA3A in primary tumors (n = 450) of hormone-receptor-negative breast cancer is associated with ARHGAP17 expression inversely, and with disease free survival. Altogether, the bevacizumab-independent VEGF/NRP1/ARHGAP17/Cdc42 regulatory network plays important roles in malignant behavior of breast cancer."xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.31645"xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/author | "Saji S."xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/author | "Sato F."xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/author | "Kiso M."xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/author | "Toi M."xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/pages | "2905-2918"xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/title | "Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network."xsd:string |
| http://purl.uniprot.org/citations/29971782 | http://purl.uniprot.org/core/volume | "143"xsd:string |
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