| http://purl.uniprot.org/citations/29972777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29972777 | http://www.w3.org/2000/01/rdf-schema#comment | "Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed that microbe-driven IFN upregulates GBPs to facilitate pathogen vacuole rupture and bacteriolysis preceding caspase-11 activation. We show here that macrophage death occurred independently of microbial-induced IFN signaling and that GBPs are dispensable for pathogen vacuole rupture. Instead, the host-intrinsic IFN status sustained sufficient GBP expression levels to drive caspase-1 and caspase-11 activation in response to cytosol-exposed bacteria. In addition, endogenous GBP levels were sufficient for the release of DNA from cytosol-exposed bacteria, preceding the cyclic GMP-AMP synthase/stimulator of interferon genes (cGAS/STING) pathway for Ifnb induction. Mice deficient for chromosome 3 GBPs were unable to mount a rapid IL-1/chemokine (C-X-C motif) ligand 1 (CXCL1) response during Legionella-induced pneumonia, with defective bacterial clearance. Our results show that rapid GBP activity is controlled by host-intrinsic cytokine signaling and that GBP activities precede immune amplification responses, including IFN induction, inflammasome activation, and cell death."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.06.012"xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Isberg R.R."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Panda A."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Coers J."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Ilyukha V."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Liu B.C."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Muendlein H.I."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Poltorak A."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/author | "Sarhan J."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/pages | "155-168.e5"xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/title | "Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses."xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/29972777 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29972777 |
| http://purl.uniprot.org/citations/29972777 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29972777 |
| http://purl.uniprot.org/uniprot/#_E0CY92-mappedCitation-29972777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29972777 |
| http://purl.uniprot.org/uniprot/#_Q0VE17-mappedCitation-29972777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29972777 |
| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-29972777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29972777 |
| http://purl.uniprot.org/uniprot/#_A0A571BF22-mappedCitation-29972777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29972777 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RQ20-mappedCitation-29972777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29972777 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-29972777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29972777 |