| http://purl.uniprot.org/citations/29975570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29975570 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic exposure of tubular renal cells to high glucose contributes to tubulointerstitial changes in diabetic nephropathy. In the present study, we identified a new fibrosis gene called galectin-1 (Gal-1), which is highly expressed in tubular cells of kidneys of type 1 and type 2 diabetic mouse models. Gal-1 protein and mRNA expression showed significant increase in kidney cortex of heterozygous Akita+/- and db/db mice compared with wild-type mice. Mouse proximal tubular cells exposed to high glucose showed significant increase in phosphorylation of Akt and Gal-1. We cloned Gal-1 promoter and identified the transcription factor AP4 as binding to the Gal-1 promoter to up-regulate its function. Transfection of cells with plasmid carrying mutations in the binding sites of AP4 to Gal-1 promoter resulted in decreased protein function of Gal-1. In addition, inhibition of Gal-1 by OTX-008 showed significant decrease in p-Akt/AP4 and protein-promoter activity of Gal-1 and fibronectin. Moreover, down-regulation of AP4 by small interfering RNA resulted in a significant decrease in protein expression and promoter activity of Gal-1. We found that kidney of Gal-1-/- mice express very low levels of fibronectin protein. In summary, Gal-1 is highly expressed in kidneys of type 1 and 2 diabetic mice, and AP4 is a major transcription factor that activates Gal-1 under hyperglycemia. Inhibition of Gal-1 by OTX-008 blocks activation of Akt and prevents accumulation of Gal-1, suggesting a novel role of Gal-1 inhibitor as a possible therapeutic target to treat renal fibrosis in diabetes.-Al-Obaidi, N., Mohan, S., Liang, S., Zhao, Z., Nayak, B. K., Li, B., Sriramarao, P., Habib, S. L. Galectin-1 is a new fibrosis protein in type 1 and type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.201800555rr"xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Al-Obaidi N."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Liang S."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Mohan S."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Sriramarao P."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Habib S.L."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/author | "Nayak B.K."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/pages | "373-387"xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/title | "Galectin-1 is a new fibrosis protein in type 1 and type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/29975570 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29975570 |
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