| http://purl.uniprot.org/citations/29983322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29983322 | http://www.w3.org/2000/01/rdf-schema#comment | "Pyramidal neurons express rich repertoires of leucine-rich repeat (LRR)-containing adhesion molecules with similar synaptogenic activity in culture. The in vivo relevance of this molecular diversity is unclear. We show that hippocampal CA1 pyramidal neurons express multiple synaptogenic LRR proteins that differentially distribute to the major excitatory inputs on their apical dendrites. At Schaffer collateral (SC) inputs, FLRT2, LRRTM1, and Slitrk1 are postsynaptically localized and differentially regulate synaptic structure and function. FLRT2 controls spine density, whereas LRRTM1 and Slitrk1 exert opposing effects on synaptic vesicle distribution at the active zone. All LRR proteins differentially affect synaptic transmission, and their combinatorial loss results in a cumulative phenotype. At temporoammonic (TA) inputs, LRRTM1 is absent; FLRT2 similarly controls functional synapse number, whereas Slitrk1 function diverges to regulate postsynaptic AMPA receptor density. Thus, LRR proteins differentially control synaptic architecture and function and act in input-specific combinations and a context-dependent manner to specify synaptic properties."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2018.06.026"xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "de Wit J."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "Gounko N.V."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "Schroeder A."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "Vennekens K.M."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "Wierda K.D."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "Ribeiro L.F."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "Vints K."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/author | "Vanderlinden J."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/pages | "329-344.e7"xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/title | "A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity."xsd:string |
| http://purl.uniprot.org/citations/29983322 | http://purl.uniprot.org/core/volume | "99"xsd:string |
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