| http://purl.uniprot.org/citations/29986998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29986998 | http://www.w3.org/2000/01/rdf-schema#comment | "Long-chain PUFAs (LC-PUFAs; C20-C22; e.g., DHA and arachidonic acid) are highly enriched in vertebrate retina, where they are elongated to very-long-chain PUFAs (VLC-PUFAs; C 28) by the elongation of very-long-chain fatty acids-4 (ELOVL4) enzyme. These fatty acids play essential roles in modulating neuronal function and health. The relevance of different lipid requirements in rods and cones to disease processes, such as age-related macular degeneration, however, remains unclear. To better understand the role of LC-PUFAs and VLC-PUFAs in the retina, we investigated the lipid compositions of whole retinas or photoreceptor outer segment (OS) membranes in rodents with rod- or cone-dominant retinas. We analyzed fatty acid methyl esters and the molecular species of glycerophospholipids (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) by GC-MS/GC-flame ionization detection and ESI-MS/MS, respectively. We found that whole retinas and OS membranes in rod-dominant animals compared with cone-dominant animals had higher amounts of LC-PUFAs and VLC-PUFAs. Compared with those of rod-dominant animals, retinas and OS membranes from cone-dominant animals also had about 2-fold lower levels of di-DHA (22:6/22:6) molecular species of glycerophospholipids. Because PUFAs are necessary for optimal G protein-coupled receptor signaling in rods, these findings suggest that cones may not have the same lipid requirements as rods."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m082495"xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Jackson S."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Reid G.E."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Woods A.S."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Anderson R.E."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Agbaga M.P."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Brush R.S."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Conley S.M."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Naash M.I."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Busik J.V."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Merriman D.K."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/author | "Lydic T.A."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/pages | "1586-1596"xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/title | "Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/29986998 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29986998 |
| http://purl.uniprot.org/citations/29986998 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29986998 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPV3-mappedCitation-29986998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29986998 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQU2-mappedCitation-29986998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29986998 |
| http://purl.uniprot.org/uniprot/#_P54846-mappedCitation-29986998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29986998 |
| http://purl.uniprot.org/uniprot/#_Q543Y0-mappedCitation-29986998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29986998 |