| http://purl.uniprot.org/citations/29987136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29987136 | http://www.w3.org/2000/01/rdf-schema#comment | "Successful vaccines rely on activating a functional humoral response that results from promoting a proper germinal center (GC) reaction. Key in this process is the activation of follicular B cells that need to acquire antigens and to present them to cognate CD4 T cells. Here, we report that follicular B cells can phagocytose large antigen-coated particles, a process thought to be exclusive of specialized antigen-presenting cells such as macrophages and dendritic cells. We show that antigen phagocytosis by B cells is BCR-driven and mechanistically dependent on the GTPase RhoG. Using Rhog-/- mice, we show that phagocytosis of antigen by B cells is important for the development of a strong GC response and the generation of high-affinity class-switched antibodies. Importantly, we show that the potentiation effect of alum, a common vaccine adjuvant, requires direct phagocytosis of alum-antigen complexes by B cells. These data suggest a new avenue for vaccination approaches by aiming to deliver 1-3 μm size antigen particles to follicular B cells."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201846016"xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Turner M."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Martinez-Martin N."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Mendoza P."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Bovolenta P."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Martinez-Riano A."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Bovolenta E.R."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Oeste C.L."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/author | "Martin-Bermejo M.J."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/pages | "e46016"xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/title | "Antigen phagocytosis by B cells is required for a potent humoral response."xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/29987136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29987136 |
| http://purl.uniprot.org/citations/29987136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29987136 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSL4-mappedCitation-29987136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29987136 |
| http://purl.uniprot.org/uniprot/#_B2KKU6-mappedCitation-29987136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29987136 |
| http://purl.uniprot.org/uniprot/#_P84096-mappedCitation-29987136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29987136 |
| http://purl.uniprot.org/uniprot/#_Q3UDZ1-mappedCitation-29987136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29987136 |
| http://purl.uniprot.org/uniprot/A0A1B0GSL4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29987136 |
| http://purl.uniprot.org/uniprot/P84096 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29987136 |