Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/29993346http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29993346http://www.w3.org/2000/01/rdf-schema#comment"

Background

Patients with thalassaemia who received regular transfusions had increased iron accumulation, leading to iron overload, which was associated with oxidative stress. Mitochondrial ferritin, encoded by the FTMT gene is an iron-storage protein in the mitochondria. The aim of this work was to investigate the expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia who were regularly transfused and rarely transfused compared with healthy controls and to evaluate the relationships of the levels of FTMT mRNA with malondialdehyde (MDA) and ferritin in these patients.

Methods

The levels of FTMT mRNA in the reticulocytes of patients (30 regularly transfused and 30 rarely transfused) and 30 healthy individuals were assessed by quantitative reverse transcription-polymerase chain reaction. The levels of ferritin and MDA were analysed by ELISA and by a thiobarbituric acid reactive substance assay, respectively.

Results

The levels of FTMT mRNA, ferritin and MDA in both groups of patients were significantly increased compared with those in the healthy controls. In addition, the levels of FTMT mRNA, ferritin and MDA in the regularly transfused patients were significantly higher than those in the rarely transfused patients. Furthermore, the relative expression levels of FTMT in patients correlated with those of MDA and ferritin.

Conclusion

These results suggest that the elevation of expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia may be associated with iron loading and oxidative stress."xsd:string
http://purl.uniprot.org/citations/29993346http://purl.org/dc/terms/identifier"doi:10.1080/10245332.2018.1496812"xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/author"Fucharoen S."xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/author"Tripatara A."xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/author"Jetsrisuparb A."xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/author"Putburee R."xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/name"Hematology"xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/pages"844-848"xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/title"Mitochondrial ferritin expression in erythroid cells from patients with alpha-thalassaemia."xsd:string
http://purl.uniprot.org/citations/29993346http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/29993346http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29993346
http://purl.uniprot.org/citations/29993346http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29993346
http://purl.uniprot.org/uniprot/#_Q8N4E7-mappedCitation-29993346http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29993346
http://purl.uniprot.org/uniprot/Q8N4E7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29993346