| http://purl.uniprot.org/citations/29997176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29997176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29997176 | http://www.w3.org/2000/01/rdf-schema#comment | "Lens epithelium-derived growth factor/p75 (LEDGF/p75, or PSIP1) is a transcriptional coactivator that tethers other proteins to gene bodies. The chromatin tethering function of LEDGF/p75 is hijacked by HIV integrase to ensure viral integration at sites of active transcription. LEDGF/p75 is also important for the development of mixed-lineage leukemia (MLL), where it tethers the MLL1 fusion complex at aberrant MLL targets, inducing malignant transformation. However, little is known about how the LEDGF/p75 protein interaction network is regulated. Here, we obtained solution structures of the complete interfaces between the LEDGF/p75 integrase binding domain (IBD) and its cellular binding partners and validated another binding partner, Mediator subunit 1 (MED1). We reveal that structurally conserved IBD-binding motifs (IBMs) on known LEDGF/p75 binding partners can be regulated by phosphorylation, permitting switching between low- and high-affinity states. Finally, we show that elimination of IBM phosphorylation sites on MLL1 disrupts the oncogenic potential of primary MLL1-rearranged leukemic cells. Our results demonstrate that kinase-dependent phosphorylation of MLL1 represents a previously unknown oncogenic dependency that may be harnessed in the treatment of MLL-rearranged leukemia."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1803909115"xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1803909115"xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Sharma S."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Sharma S."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Rezacova P."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Rezacova P."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Veverka V."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Veverka V."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Lepsik M."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Lepsik M."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Srb P."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Srb P."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Novak P."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Novak P."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Van Belle S."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Van Belle S."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Christ F."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Christ F."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "De Rijck J."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "De Rijck J."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Debyser Z."xsd:string |
| http://purl.uniprot.org/citations/29997176 | http://purl.uniprot.org/core/author | "Debyser Z."xsd:string |