| http://purl.uniprot.org/citations/30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30001323 | http://www.w3.org/2000/01/rdf-schema#comment | "Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of sleep. We found that these short-sleeping mutants share a common phenotype of sensitivity to acute oxidative stress, exhibiting shorter survival times than controls. We further showed that increasing sleep in wild-type flies using genetic or pharmacological approaches increases survival after oxidative challenge. Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep. Together, these results support the hypothesis that a key function of sleep is to defend against oxidative stress and also point to a reciprocal role for reactive oxygen species (ROS) in neurons in the regulation of sleep."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.2005206"xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "O'Connor R.M."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "Leong S."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "Canman J.C."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "Stavropoulos N."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "Shirasu-Hiza M."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "Hill V.M."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "Irobunda I.S."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/author | "Sissoko G.B."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/pages | "e2005206"xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/title | "A bidirectional relationship between sleep and oxidative stress in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/30001323 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30001323 |
| http://purl.uniprot.org/citations/30001323 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30001323 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFT5-mappedCitation-30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30001323 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEX2-mappedCitation-30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30001323 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LEU0-mappedCitation-30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30001323 |
| http://purl.uniprot.org/uniprot/#_A0A0S0WNY8-mappedCitation-30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30001323 |
| http://purl.uniprot.org/uniprot/#_P61851-mappedCitation-30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30001323 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LID7-mappedCitation-30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30001323 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LGQ1-mappedCitation-30001323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30001323 |