| http://purl.uniprot.org/citations/30002415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30002415 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleoside diphosphate kinase B (NDPK-B) acts as a protective factor in the retinal vasculature. NDPK-B deficiency leads to retinal vasoregression mimicking diabetic retinopathy (DR). Angiopoetin 2 (Ang-2), an initiator of retinal vasoregression in DR, is upregulated in NDPK-B deficient retinas and in NDPK-B depleted endothelial cells (ECs) in vitro. We therefore investigated the importance of Ang-2 in NDPK-B deficient retinas and characterized the mechanisms of Ang-2 upregulation upon NDPK-B depletion in cultured ECs. The crucial role of retinal Ang-2 in the initiation of vasoregression was verified by crossing NDPK-B deficient with Ang-2 haplodeficient mice. On the molecular level, FoxO1, a transcription factor regulating Ang-2, was upregulated in NDPK-B depleted ECs. Knockdown of FoxO1 abolished the elevation of Ang-2 induced by NDPK-B depletion. Furthermore O-GlcNAcylated FoxO1 was found preferentially in the nucleus. An increased O-GlcNAcylation of FoxO1 was revealed upon NDPK-B depletion. In accordance, the inhibition of protein O-GlcNAcylation normalized NDPK-B depletion induced Ang-2 upregulation. In summary, we demonstrated that the upregulation of Ang-2 upon NDPK-B deficiency is driven by O-GlcNAcylation of FoxO1. Our data provide evidence for a central role of protein O-GlcNAcylation in NDPK-B associated vascular damage and point to the hexosamine pathway as an important target in retinal vasoregression."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-28892-y"xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/author | "Chatterjee A."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/author | "Shan S."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/author | "Wieland T."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/author | "Hammes H.P."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/pages | "10581"xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/title | "O-GlcNAcylation of FoxO1 mediates nucleoside diphosphate kinase B deficiency induced endothelial damage."xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30002415 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30002415 |
| http://purl.uniprot.org/citations/30002415 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30002415 |
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