| http://purl.uniprot.org/citations/30006413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30006413 | http://www.w3.org/2000/01/rdf-schema#comment | "CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.118.200572"xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/author | "Newfeld S.J."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/author | "Takaesu N.T."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/author | "Tran N.L."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/author | "Dimitriadou A."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/author | "Consoulas C."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/author | "Goldsmith S.L."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/pages | "2979-2990"xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/title | "CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/30006413 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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