| http://purl.uniprot.org/citations/30008325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30008325 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs/SOX9 axis in regulating skeletogenesis through its expression in undifferentiated mesenchymal cells. Inactivation of Raptor, a component of mTORC1, in limb buds before mesenchymal condensations resulted in a marked loss of both cartilage and bone. Mechanistically, we demonstrated that mTORC1 selectively controls the RNA translation of Sox9, which harbors a 5' terminal oligopyrimidine tract motif, via inhibition of the 4E-BPs. Indeed, introduction of Sox9 or a knockdown of 4E-BP1/2 in undifferentiated mesenchymal cells markedly rescued the deficiency of the condensation observed in Raptor-deficient mice. Furthermore, introduction of the Sox9 transgene rescued phenotypes of deficient skeletal growth in Raptor-deficient mice. These findings highlight a critical role of mTORC1 in mammalian skeletogenesis, at least in part, through translational control of Sox9 RNA."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2018.05.020"xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Ozaki K."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Ohno M."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Kitaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Horie T."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Kitabatake M."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Park G."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Kaneda K."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Onishi Y."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Fukasawa K."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Ishigaki Y."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Manabe T."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Hiraiwa M."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Hinoi E."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Kanayama T."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/author | "Iezaki T."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/pages | "228-241"xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/title | "Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis."xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/30008325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30008325 |