| http://purl.uniprot.org/citations/30010626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30010626 | http://www.w3.org/2000/01/rdf-schema#comment | "The biological activity of 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] remains controversial, but it has been suggested that it contributes to fracture healing. Cyp24a1-/-mice, synthesizing no 24R,25(OH)2D3, show suboptimal endochondral ossification during fracture repair, with smaller callus and reduced stiffness. These defects were corrected by 24R,25(OH)2D3 treatment, but not by 1,25-dihydroxyvitamin D3. Microarrays with Cyp24a1-/-callus mRNA identified FAM57B2 as a mediator of the 24R,25(OH)2D3 effect. FAM57B2 produced lactosylceramide (LacCer) upon specific binding of 24R,25(OH)2D3. Fam57b inactivation in chondrocytes (Col2-Cre Fam57bfl/fl) phenocopied the callus formation defect of Cyp24a1-/-mice. LacCer or 24R,25(OH)2D3 injections restored callus volume, stiffness, and mineralized cartilage area in Cyp24a1-null mice, but only LacCer rescued Col2-Cre Fam57bfl/fl mice. Gene expression in callus tissue suggested that the 24R,25(OH)2D3/FAM57B2 cascade affects cartilage maturation. We describe a previously unrecognized pathway influencing endochondral ossification during bone repair through LacCer production upon binding of 24R,25(OH)2D3 to FAM57B2. Our results identify potential new approaches to ameliorate fracture healing."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci98093"xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Kaufmann M."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Jones G."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Akhouayri O."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "St-Arnaud R."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Martineau C."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Arabian A."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Naja R.P."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Husseini A."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/author | "Hamade B."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/pages | "3546-3557"xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/title | "Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2."xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/30010626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30010626 |
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