| http://purl.uniprot.org/citations/30017584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30017584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30017584 | http://www.w3.org/2000/01/rdf-schema#comment | "The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is intrinsically disordered and interacts with many DNA damage response (DDR) proteins, including the kinases ataxia telangiectasia mutated (ATM) and DNA-PKcs and the classical non-homologous end joining (cNHEJ) factors Ku70, Ku80, XRCC4, XLF, PAXX, and XRCC4. MRI forms large multimeric complexes that depend on its N and C termini and localizes to DNA double-strand breaks (DSBs), where it promotes the retention of DDR factors. Mice deficient in MRI and XLF exhibit embryonic lethality at a stage similar to those deficient in the core cNHEJ factors XRCC4 or DNA ligase IV. Moreover, MRI is required for cNHEJ-mediated DSB repair in XLF-deficient lymphocytes. We propose that MRI is an adaptor that, through multivalent interactions, increases the avidity of DDR factors to DSB-associated chromatin to promote cNHEJ."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2018.06.018"xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2018.06.018"xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Gross M.L."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Gross M.L."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Johnson T.E."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Johnson T.E."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Lee B.J."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Lee B.J."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Sleckman B.P."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Sleckman B.P."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Paull T.T."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Paull T.T."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Mosammaparast N."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Mosammaparast N."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Amarasinghe G.K."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Amarasinghe G.K."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Chaudhuri J."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Chaudhuri J."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Johnson B."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Johnson B."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Tyler J.K."xsd:string |
| http://purl.uniprot.org/citations/30017584 | http://purl.uniprot.org/core/author | "Tyler J.K."xsd:string |