| http://purl.uniprot.org/citations/30018139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30018139 | http://www.w3.org/2000/01/rdf-schema#comment | "The Lin-c-Kit+ Sca-1+ cell population in the bone marrow (BM) serves as the direct precursor for differentiation of myeloid cells. In this study, we report that deficiency in Fpr2, a G protein-coupled chemoattractant receptor in mice, is associated with reduced BM nucleated cells, including CD31+Ly6C+ (granulocytes and monocytes), CD31-/Ly6Cint (granuloid cells), and CD31-/Ly6Chigh (predominantly monocytes) cells. In particular, the number of Lin-c-Kit+Sca-1+ (LKS) cells was reduced in Fpr2-/- mouse BM. This was supported by observations of the reduced incorporation of intraperitoneally injected bromodeoxyuridine by cells in the c-Kit+ population from Fpr2-/- mouse BM. Purified c-Kit+ cells from Fpr2-/- mice showed reduced expansion when cultured in vitro with stem cell factor (SCF). SCF/c-Kit-mediated phosphorylation of P38, STAT1, Akt (Thr-308), and Akt (Ser-473) was also significantly reduced in c-Kit+ cells from Fpr2-/- mice. Furthermore, Fpr2 agonists enhanced SCF-induced proliferation of c-Kit+ cells. Colony-forming unit assays revealed that CFU-granulocyte-macrophage formation of BM cells from Fpr2-/- mice was significantly reduced. After heat-inactivated bacterial stimulation in the airway, the expansion of c-kit+ Sca-1+ cells in BM and recruitment of Ly6G+ cells to the lungs and CD11b+Ly6C+TNFα+ cells to the spleen of Fpr2-/- mice was significantly reduced. These results demonstrate an important role for Fpr2 in the development of myeloid lineage precursors in mouse BM."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra118.002683"xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Bao Z."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Gong W."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Yoshimura T."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Tang P."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Le Y."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Wang J.M."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "He T."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/author | "Tessarollo L."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/pages | "13452-13463"xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/title | "Deficiency in Fpr2 results in reduced numbers of Lin-cKit+Sca1+ myeloid progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/30018139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30018139 |
| http://purl.uniprot.org/citations/30018139 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30018139 |
| http://purl.uniprot.org/uniprot/#_A0A087WNT7-mappedCitation-30018139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30018139 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPU6-mappedCitation-30018139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30018139 |
| http://purl.uniprot.org/uniprot/#_A4ZVL1-mappedCitation-30018139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30018139 |
| http://purl.uniprot.org/uniprot/#_C7ENW2-mappedCitation-30018139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30018139 |