| http://purl.uniprot.org/citations/30018535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30018535 | http://www.w3.org/2000/01/rdf-schema#comment | "A pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter accompanied by compromised remyelination. Demyelinated lesions are deeply associated with oligodendrocyte apoptosis and a robust inflammatory response. Although various studies point towards a noxious role of inflammation in MS, others emphasize a positive role for the innate immune cells in disease progression. A cytokine well-known to stimulate cell survival, proliferation and differentiation of myeloid cells, macrophage colony-stimulating factor (mCSF), was administered to mice during a 5 week-long cuprizone diet. Treated mice exhibited reduced myelin loss during the demyelination phase, together with an increased number of microglia and oligodendrocyte precursor cells in lesion sites. Tamoxifen-induced conditional deletion of the mCSF receptor in microglia from cuprizone-fed mice caused aberrant myelin debris accumulation in the corpus callosum and reduced microglial phagocytic response. mCSF therefore plays a key role in stimulating myelin clearance by the brain innate immune cells, which is a prerequisite for proper remyelination and myelin repair processes."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.org/dc/terms/identifier | "doi:10.3389/fncel.2018.00178"xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "Laflamme N."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "Rivest S."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "Tremblay M.E."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "Prefontaine P."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "Bernier J."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "Cisbani G."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "Srour Y."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/author | "St-Pierre M.K."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/name | "Front Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/pages | "178"xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/title | "mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis."xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/30018535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30018535 |
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