| http://purl.uniprot.org/citations/30022044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30022044 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of EZH2 in estrogen receptor negative (ER-) breast cancer promotes metastasis. EZH2 has been mainly studied as the catalytic component of the Polycomb Repressive Complex 2 (PRC2) that mediates gene repression by trimethylating histone H3 at lysine 27 (H3K27me3). However, how EZH2 drives metastasis despite the low H3K27me3 levels observed in ER-breast cancer is unknown. Here we show that in human invasive carcinomas and distant metastases, cytoplasmic EZH2 phosphorylated at T367 is significantly associated with ER-disease and low H3K27me3 levels. p38-mediated EZH2 phosphorylation at T367 promotes EZH2 cytoplasmic localization and potentiates EZH2 binding to vinculin and other cytoskeletal regulators of cell migration and invasion. Ectopic expression of a phospho-deficient T367A-EZH2 mutant is sufficient to inhibit EZH2 cytoplasmic expression, disrupt binding to cytoskeletal regulators, and reduce EZH2-mediated adhesion, migration, invasion, and development of spontaneous metastasis. These results point to a PRC2-independent non-canonical mechanism of EZH2 pro-metastatic function."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-05078-8"xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Chen Y.C."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Nesvizhskii A.I."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Basrur V."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Anwar T."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Yoon E."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Gonzalez M.E."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Arellano-Garcia C."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Kleer C.G."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Nikolovska-Coleska Z."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Kidwell K.M."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Ropa J."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Grigsby S."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/author | "Muntean A."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/pages | "2801"xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/title | "p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis."xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30022044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30022044 |
| http://purl.uniprot.org/citations/30022044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30022044 |
| http://purl.uniprot.org/uniprot/#_F2YMM1-mappedCitation-30022044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30022044 |