| http://purl.uniprot.org/citations/30022068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30022068 | http://www.w3.org/2000/01/rdf-schema#comment | "Malignant tumors typically undergo an atavistic regression characterized by the overexpression of embryonic genes and proto-oncogenes, including a variety of cancer/testis antigens (CTAs) that are testis-derived and are not expressed or expressed in trace amounts in somatic tissues. Based on this theory, we established a new method to identify unknown CTAs, the spermatogenic cells-specific monoclonal antibody-defined cancer/testis antigen (SADA) method. Using the SADA method, we identified BAP31 as a novel CTA and confirmed that BAP31 expression is associated with progression and metastasis of several cancers, particularly in cervical cancer. We found that BAP31 was significantly upregulated in stage I, II, and III cervical cancer patients and highly correlated with poor clinic outcomes. We further demonstrated that BAP31 regulates cervical cancer cell proliferation by arresting the cell cycle at the G0/G1 stage and that depletion of BAP31 inhibits hyper-proliferation. Moreover, depletion of BAP31 inhibits cervical cancer cell invasion and migration by regulating the expression and subcellular localization of Drebrin, M-RIP, SPECC1L, and Nexilin, and then affect the cytoskeleton assemblage. Finally, the depletion of BAP31 prevents cervical cancer progression and metastasis in vivo. These findings provide a new method for identifying novel CTAs as well as mechanistic insights into how BAP31 regulates cervical cancer hyper-proliferation and metastasis."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-018-0824-2"xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Song C."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Tao L."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Fan W."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Jiang D."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Jin B."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/author | "Dang E."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/pages | "791"xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/title | "BAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression."xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30022068 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30022068 |
| http://purl.uniprot.org/citations/30022068 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30022068 |
| http://purl.uniprot.org/uniprot/#_P51572-mappedCitation-30022068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30022068 |