| http://purl.uniprot.org/citations/30022158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30022158 | http://www.w3.org/2000/01/rdf-schema#comment | "In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair-which requires a 3' overhang-and classical non-homologous end joining, which can join unresected ends1,2. BRCA1-mutant cancers show minimal resection of double-strand breaks, which renders them deficient in homology-directed repair and sensitive to inhibitors of poly(ADP-ribose) polymerase 1 (PARP1)3-8. When BRCA1 is absent, the resection of double-strand breaks is thought to be prevented by 53BP1, RIF1 and the REV7-SHLD1-SHLD2-SHLD3 (shieldin) complex, and loss of these factors diminishes sensitivity to PARP1 inhibitors4,6-9. Here we address the mechanism by which 53BP1-RIF1-shieldin regulates the generation of recombinogenic 3' overhangs. We report that CTC1-STN1-TEN1 (CST)10, a complex similar to replication protein A that functions as an accessory factor of polymerase-α (Polα)-primase11, is a downstream effector in the 53BP1 pathway. CST interacts with shieldin and localizes with Polα to sites of DNA damage in a 53BP1- and shieldin-dependent manner. As with loss of 53BP1, RIF1 or shieldin, the depletion of CST leads to increased resection. In BRCA1-deficient cells, CST blocks RAD51 loading and promotes the efficacy of PARP1 inhibitors. In addition, Polα inhibition diminishes the effect of PARP1 inhibitors. These data suggest that CST-Polα-mediated fill-in helps to control the repair of double-strand breaks by 53BP1, RIF1 and shieldin."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-018-0324-7"xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Takai K."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Durocher D."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Gong Y."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Zimmermann M."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "de Lange T."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Bianchi A."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Takai H."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Kibe T."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Lottersberger F."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/author | "Mirman Z."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/pages | "112-116"xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/title | "53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polalpha-dependent fill-in."xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://purl.uniprot.org/core/volume | "560"xsd:string |
| http://purl.uniprot.org/citations/30022158 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30022158 |
| http://purl.uniprot.org/citations/30022158 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30022158 |
| http://purl.uniprot.org/uniprot/#_A0A087WP26-mappedCitation-30022158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30022158 |
| http://purl.uniprot.org/uniprot/#_A0A087WPE1-mappedCitation-30022158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30022158 |
| http://purl.uniprot.org/uniprot/#_A0A087WPK5-mappedCitation-30022158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30022158 |
| http://purl.uniprot.org/uniprot/#_A0A5H1ZRL7-mappedCitation-30022158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30022158 |
| http://purl.uniprot.org/uniprot/#_A0A0R9RRX7-mappedCitation-30022158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30022158 |