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http://purl.uniprot.org/citations/30031767http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30031767http://www.w3.org/2000/01/rdf-schema#comment"Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.org/dc/terms/identifier"doi:10.1053/j.gastro.2018.07.019"xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Herker E."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Korner C."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Schramm C."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Altfeld M."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Garcia-Beltran W.F."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Holzemer A."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Martrus G."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Schulze Zur Wiesch J."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Richert L."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Ziegler A.E."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Dandri M."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Kah J."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Schobel A."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Lunemann S."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Langeneckert A.E."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Oldhafer K.J."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Fittje P."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Hess L.U."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/author"Poch T."xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/name"Gastroenterology"xsd:string
http://purl.uniprot.org/citations/30031767http://purl.uniprot.org/core/pages"1366-1371.e3"xsd:string