| http://purl.uniprot.org/citations/30033219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30033219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30033219 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadherin-23 (CDH23) is an essential component of hair-cell tip links, fine filaments that mediate inner-ear mechanotransduction. The extracellular domain of CDH23 forms about three-fourths of the tip link with 27 extracellular cadherin (EC) repeats that are structurally similar but not identical to each other. Calcium (Ca2+) coordination at the EC linker regions is key for tip-link elasticity and function. There are ∼116 sites in CDH23 affected by deafness-causing mutations, many of which alter conserved Ca2+-binding residues. Here we present crystal structures showing 18 CDH23 EC repeats, including the most and least conserved, a fragment carrying disease mutations, and EC repeats with non-canonical Ca2+-binding motif sequences and unusual secondary structure. Complementary experiments show deafness mutations' effects on stability and affinity for Ca2+. Additionally, a model of nine contiguous CDH23 EC repeats reveals helicity and potential parallel dimerization faces. Overall, our studies provide detailed structural insight into CDH23 function in mechanotransduction."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2018.06.003"xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2018.06.003"xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Sotomayor M."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Sotomayor M."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "De-la-Torre P."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "De-la-Torre P."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Jaiganesh A."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Jaiganesh A."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Patel A.A."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Patel A.A."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Termine D.J."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Termine D.J."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Velez-Cortes F."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/author | "Velez-Cortes F."xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/pages | "1210-1225.e4"xsd:string |
| http://purl.uniprot.org/citations/30033219 | http://purl.uniprot.org/core/pages | "1210-1225.e4"xsd:string |