| http://purl.uniprot.org/citations/30038024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30038024 | http://www.w3.org/2000/01/rdf-schema#comment | "SLC30A8 encodes a zinc transporter that is primarily expressed in the pancreatic islets of Langerhans. In β-cells it transports zinc into insulin-containing secretory granules. Loss-of-function (LOF) mutations in SLC30A8 protect against type 2 diabetes in humans. In this study, we generated a knockin mouse model carrying one of the most common human LOF mutations for SLC30A8, R138X. The R138X mice had normal body weight, glucose tolerance, and pancreatic β-cell mass. Interestingly, in hyperglycemic conditions induced by the insulin receptor antagonist S961, the R138X mice showed a 50% increase in insulin secretion. This effect was not associated with enhanced β-cell proliferation or mass. Our data suggest that the SLC30A8 R138X LOF mutation may exert beneficial effects on glucose metabolism by increasing the capacity of β-cells to secrete insulin under hyperglycemic conditions."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1721418115"xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Gomez D."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Carrat G."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Rutter G.A."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Murphy A.J."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Yancopoulos G.D."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Rojas J."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Xin Y."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Gromada J."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Zambrowicz B."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Na E."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Bhavsar R."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Kleiner S."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Chabosseau P."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Cavino K."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Megra B."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/author | "Dominguez-Gutierrez G."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/pages | "E7642-E7649"xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/title | "Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity."xsd:string |
| http://purl.uniprot.org/citations/30038024 | http://purl.uniprot.org/core/volume | "115"xsd:string |