| http://purl.uniprot.org/citations/30041403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30041403 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuroglobin is an endogenous neuroprotective protein, but the underlying neuroprotective mechanisms remain to be elucidated. Our previous yeast two-hybrid screening study identified that Dishevelled-1, a key hub protein of Wnt/β-Catenin signaling, is an interaction partner of Neuroglobin. In this study, we further examined the role of Neuroglobin in regulating Dishevelled-1 and the downstream Wnt/β-Catenin and NFκB signaling pathway. We found that Neuroglobin directly interacts with Dishevelled-1 by co-immunoprecipitation, and the two proteins are co-localized in both cytoplasma and nucleus of SK-N-SH cells. Moreover, the ectopic expression of Neuroglobin promotes the degradation of exogenous and endogenous Dishevelled-1 through the proteasomal degradation pathway. Furthermore, our results showed that Neuroglobin significantly inhibits the luciferase activity of Topflash reporter and the expression of β-Catenin mediated by Dishevelled-1 in SK-N-SH cells. In addition, we also documented that Neuroglobin enhances TNF-α-induced NFκB activation via down-regulating Dishevelled-1. Finally, 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) assays showed that Neuroglobin is an important neuroprotectant that protects SK-N-SH cells from TNF-α-induced decrease in cell viability. Taken together, these findings demonstrated that Neuroglobin functions as an important modulator of the Wnt/β-Catenin and NFκB signaling pathway through regulating Dishevelled-1."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms19072133"xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Liu N."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Wei C."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Long S."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Tang F."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Xiang S."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Shu P."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/author | "Xun Y."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/pages | "E2133"xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/title | "Neuroglobin Regulates Wnt/beta-Catenin and NFkappaB Signaling Pathway through Dvl1."xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/30041403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30041403 |
| http://purl.uniprot.org/citations/30041403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30041403 |
| http://purl.uniprot.org/uniprot/#_A0M8W9-mappedCitation-30041403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30041403 |
| http://purl.uniprot.org/uniprot/#_Q9NPG2-mappedCitation-30041403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30041403 |
| http://purl.uniprot.org/uniprot/A0M8W9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30041403 |