| http://purl.uniprot.org/citations/30045946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30045946 | http://www.w3.org/2000/01/rdf-schema#comment | "Tle/Groucho proteins are transcriptional corepressors interacting with Tcf/Lef and Runx transcription factors, but their physiological roles in T cell development remain unknown. Conditional targeting of Tle1, Tle3 and Tle4 revealed gene dose-dependent requirements for Tle proteins in CD8+ lineage cells. Upon ablating all three Tle proteins, generation of CD8+ T cells was greatly diminished, largely owing to redirection of MHC-I-selected thymocytes to CD4+ lineage; the remaining CD8-positive T cells showed aberrant up-regulation of CD4+ lineage-associated genes including Cd4, Thpok, St8sia6, and Foxp3 Mechanistically, Tle3 bound to Runx-occupied Thpok silencer, in post-selection double-positive thymocytes to prevent excessive ThPOK induction and in mature CD8+ T cells to silence Thpok expression. Tle3 also bound to Tcf1-occupied sites in a few CD4+ lineage-associated genes, including Cd4 silencer and St8sia6 introns, to repress their expression in mature CD8+ T cells. These findings indicate that Tle corepressors are differentially partitioned to Runx and Tcf/Lef complexes to instruct CD8+ lineage choice and cooperatively establish CD8+ T cell identity, respectively."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20171514"xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Peng W."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Yu S."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Xing S."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Xue H.H."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Ramasamy S."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Taniuchi I."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Sweetser D.A."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Seo W."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Shao P."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/author | "Wheat J.C."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/pages | "2211-2226"xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/title | "Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity."xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://purl.uniprot.org/core/volume | "215"xsd:string |
| http://purl.uniprot.org/citations/30045946 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30045946 |
| http://purl.uniprot.org/citations/30045946 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30045946 |