| http://purl.uniprot.org/citations/30050136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30050136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30050136 | http://www.w3.org/2000/01/rdf-schema#comment | "Necroptosis complements apoptosis as a host defense pathway to stop virus infection. Herpes simplex virus shows a propensity to trigger necroptosis of mouse cells and mice even though cell death is blocked in human cells through UL39-encoded ICP6. This ribonucleotide reductase large subunit (R1) nucleates RHIM-dependent oligomerization of RIP3 kinase (RIPK3, also known as RIP3) in mouse cells but inhibits activation in cells from the natural human host. By interrogating the comparative behavior of ICP6-deficient viruses in mouse and human cells, here we unveil virus-induced necroptosis mediated by Z-DNA-binding protein 1 (ZBP1, also known as DAI). ZBP1 acts as a pathogen sensor to detect nascent RNA transcripts rather than input viral DNA or viral DNA generated through replication. Consistent with the implicated role of virus-induced necroptosis in restricting infection, viral pathogenesis is restored in Zbp1-/-, Ripk3-/- and Mlkl-/- mice. Thus, in addition to direct activation of RIPK3 via ICP6, HSV1 infection in mice and mouse cells triggers virus-induced necroptosis through ZBP1. Importantly, virus-induced necroptosis is also induced in human HT-29 cells by ICP6 mutant viruses; however, ZBP1 levels must be elevated for this pathway to be active. Thus, our studies reveal a common, species-independent role of this nucleic acid sensor to detect the presence of this virus. HSV1 ICP6 functions as a bona fide RHIM signaling inhibitor to block virus-induced necroptosis in its natural host. Altogether, ZBP1-dependent restriction of herpesvirus infection emerges as a potent antiviral armament of the innate immune system."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-018-0868-3"xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-018-0868-3"xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Kaiser W.J."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Kaiser W.J."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Mocarski E.S."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Mocarski E.S."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Fisher A."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Fisher A."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Carette J.E."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Carette J.E."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Upton J.W."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Upton J.W."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Lane R."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Lane R."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Dovey C.M."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Dovey C.M."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Gilley R.P."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Gilley R.P."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Landsteiner V.J."xsd:string |
| http://purl.uniprot.org/citations/30050136 | http://purl.uniprot.org/core/author | "Landsteiner V.J."xsd:string |