| http://purl.uniprot.org/citations/3005478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3005478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3005478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3005478 | http://www.w3.org/2000/01/rdf-schema#comment | "BHK-21 cells readily produce tumours in athymic nude mice, but BHK-21 cells persistently infected with wild-type vesicular stomatitis virus (VSV) do not. However, rare persistently infected virus-shedding tumours (VSV-P tumour cells) were independently derived by in vivo selection on three different occasions. Cloned viruses isolated from each of these (VSV-P virus mutants) carried mutations determining the VSV-P phenotype because they all allowed growth of virus-shedding tumours in nude mice when they were used to persistently infect normal (unselected) BHK-21 cells. Treatment of nude mice with anti-asialo-GM1 allowed BHK cells persistently infected with wild-type VSV to form tumours, and BHK cells persistently infected with VSV-P were resistant to natural killer (NK) cells in vitro; this implicates NK cells in the in vivo rejection of persistently infected tumours and in the selection of the VSV-P variant. In this paper, we have sequenced the glycoprotein (G protein), matrix (M) and non-structural (NS) proteins of three independently derived VSV-P type mutants to find mutations associated with in vivo passage of persistently infected nude mouse tumours and with resistance to NK cells. We found extensive mutation in the G protein of VSV-P but relatively few mutations in the M and NS proteins. This suggests but does not prove a role for the G protein in NK cell killing of infected cells."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.org/dc/terms/identifier | "doi:10.1099/0022-1317-67-3-441"xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.org/dc/terms/identifier | "doi:10.1099/0022-1317-67-3-441"xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/author | "Holland J.J."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/author | "Holland J.J."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/author | "Holland J.J."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/author | "Vandepol S.B."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/author | "Vandepol S.B."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/author | "Vandepol S.B."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/pages | "441-451"xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/pages | "441-451"xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/pages | "441-451"xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/title | "Evolution of vesicular stomatitis virus in athymic nude mice: mutations associated with natural killer cell selection."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/title | "Evolution of vesicular stomatitis virus in athymic nude mice: mutations associated with natural killer cell selection."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/title | "Evolution of vesicular stomatitis virus in athymic nude mice: Mutations associated with natural killer cell selection."xsd:string |
| http://purl.uniprot.org/citations/3005478 | http://purl.uniprot.org/core/volume | "67"xsd:string |