| http://purl.uniprot.org/citations/30056257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30056257 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute lung injury (ALI) is a serious complication among patients with acute kidney injury (AKI) that is a systemic inflammatory disease with high morbidity and mortality. The pathophysiology of AKI-associated ALI is poorly understood. G-CSF regulates the production and function of neutrophils that mediate lung injury via elastase and other mediators. Here, we used a mouse model of adenine-induced AKI to determine the roles of G-CSF and neutrophil elastase in AKI-associated ALI. We confirmed that ALI was associated with high serum G-CSF levels, and elevated neutrophil elastase activity in the lungs and serum of mice with adenine-induced AKI. Systemic administration of G-CSF-specific neutralizing antibody normalized granulopoiesis, pulmonary neutrophil infiltration, and neutrophil elastase activity, conferring improved lung architecture in mice with adenine-induced AKI. Further studies revealed that macrophages secreted G-CSF upon urea stimulation. Consequently, G-CSF could be a target for new anti-lung injury strategy in patients with AKI."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2018.07.032"xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Qin F."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Qiu C."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Shi B."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/author | "Jing W."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/pages | "1-8"xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/title | "G-CSF mediates lung injury in mice with adenine-induced acute kidney injury."xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/30056257 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30056257 |
| http://purl.uniprot.org/citations/30056257 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30056257 |
| http://purl.uniprot.org/uniprot/#_Q0VB73-mappedCitation-30056257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30056257 |
| http://purl.uniprot.org/uniprot/#_P09920-mappedCitation-30056257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30056257 |
| http://purl.uniprot.org/uniprot/#_Q62230-mappedCitation-30056257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30056257 |
| http://purl.uniprot.org/uniprot/#_G3X8X6-mappedCitation-30056257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30056257 |
| http://purl.uniprot.org/uniprot/#_H9KUZ2-mappedCitation-30056257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30056257 |
| http://purl.uniprot.org/uniprot/#_H9KUZ3-mappedCitation-30056257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30056257 |