| http://purl.uniprot.org/citations/30056832 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30056832 | http://www.w3.org/2000/01/rdf-schema#comment | "NMDA-type glutamate receptors (NMDARs) are ligand-gated ion channels that mediate excitatory neurotransmission in the CNS. Here we describe functional and single-channel properties of triheteromeric GluN1/GluN2A/GluN2C receptors, which contain two GluN1, one GluN2A, and one GluN2C subunits. This NMDAR has three conductance levels and opens in bursts similar to GluN1/GluN2A receptors but with a single-channel open time and open probability reminiscent of GluN1/GluN2C receptors. The deactivation time course of GluN1/GluN2A/GluN2C receptors is intermediate to GluN1/GluN2A and GluN1/GluN2C receptors and is not dominated by GluN2A or GluN2C. We show that triheteromeric GluN1/GluN2A/GluN2C receptors are the predominant NMDARs in cerebellar granule cells and propose that co-expression of GluN2A and GluN2C in cerebellar granule cells occludes cell surface expression of diheteromeric GluN1/GluN2C receptors. This new insight into neuronal GluN1/GluN2A/GluN2C receptors highlights the complexity of NMDAR signaling in the CNS."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2018.06.010"xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "Yuan H."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "Khatri A."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "Yi F."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "Swanger S.A."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "Hansen K.B."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "Traynelis S.F."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/author | "DiRaddo J.O."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/pages | "315-328.e5"xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/title | "Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells."xsd:string |
| http://purl.uniprot.org/citations/30056832 | http://purl.uniprot.org/core/volume | "99"xsd:string |
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