| http://purl.uniprot.org/citations/30060147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30060147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30060147 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptome of the venom duct of the Atlantic piscivorous cone species Chelyconus ermineus (Born, 1778) was determined. The venom repertoire of this species includes at least 378 conotoxin precursors, which could be ascribed to 33 known and 22 new (unassigned) protein superfamilies, respectively. Most abundant superfamilies were T, W, O1, M, O2, and Z, accounting for 57% of all detected diversity. A total of three individuals were sequenced showing considerable intraspecific variation: each individual had many exclusive conotoxin precursors, and only 20% of all inferred mature peptides were common to all individuals. Three different regions (distal, medium, and proximal with respect to the venom bulb) of the venom duct were analyzed independently. Diversity (in terms of number of distinct members) of conotoxin precursor superfamilies increased toward the distal region whereas transcripts detected toward the proximal region showed higher expression levels. Only the superfamilies A and I3 showed statistically significant differential expression across regions of the venom duct. Sequences belonging to the alpha (motor cabal) and kappa (lightning-strike cabal) subfamilies of the superfamily A were mainly detected in the proximal region of the venom duct. The mature peptides of the alpha subfamily had the α4/4 cysteine spacing pattern, which has been shown to selectively target muscle nicotinic-acetylcholine receptors, ultimately producing paralysis. This function is performed by mature peptides having a α3/5 cysteine spacing pattern in piscivorous cone species from the Indo-Pacific region, thereby supporting a convergent evolution of piscivory in cones."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.org/dc/terms/identifier | "doi:10.1093/gbe/evy150"xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.org/dc/terms/identifier | "doi:10.1093/gbe/evy150"xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Zardoya R."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Zardoya R."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Abalde S."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Abalde S."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Afonso C.M."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Afonso C.M."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Tenorio M.J."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/author | "Tenorio M.J."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/name | "Genome Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/name | "Genome Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/pages | "2643-2662"xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/pages | "2643-2662"xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/title | "Conotoxin diversity in Chelyconus ermineus (Born, 1778) and the convergent origin of piscivory in the Atlantic and Indo-Pacific cones."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/title | "Conotoxin diversity in Chelyconus ermineus (Born, 1778) and the convergent origin of piscivory in the Atlantic and Indo-Pacific cones."xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30060147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30060147 |
| http://purl.uniprot.org/citations/30060147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30060147 |