| http://purl.uniprot.org/citations/30061412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30061412 | http://www.w3.org/2000/01/rdf-schema#comment | "Warsaw breakage syndrome, a developmental disorder caused by mutations in the DDX11/ChlR1 helicase, shows cellular features of genome instability similar to Fanconi anemia (FA). Here we report that DDX11-deficient avian DT40 cells exhibit interstrand crosslink (ICL)-induced chromatid breakage, with DDX11 functioning as backup for the FA pathway in regard to ICL repair. Importantly, we establish that DDX11 acts jointly with the 9-1-1 checkpoint clamp and its loader, RAD17, primarily in a postreplicative fashion, to promote homologous recombination repair of bulky lesions, but is not required for intra-S checkpoint activation or efficient fork progression. Notably, we find that DDX11 also promotes diversification of the chicken Ig-variable gene, a process triggered by programmed abasic sites, by facilitating both hypermutation and homeologous recombination-mediated gene conversion. Altogether, our results uncover that DDX11 orchestrates jointly with 9-1-1 and its loader, RAD17, DNA damage tolerance at sites of bulky lesions, and endogenous abasic sites. These functions may explain the essential roles of DDX11 and its similarity with 9-1-1 during development."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1803110115"xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/author | "Hirota K."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/author | "Miyata K."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/author | "Takata M."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/author | "Branzei D."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/author | "Kawasumi R."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/author | "Ooka M."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/pages | "8412-8417"xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/title | "Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites."xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/30061412 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30061412 |
| http://purl.uniprot.org/citations/30061412 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30061412 |
| http://purl.uniprot.org/uniprot/#_O75943-mappedCitation-30061412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30061412 |
| http://purl.uniprot.org/uniprot/O75943 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30061412 |